Hi,
until pythonnet 2.1.0 it was possible to call functions with the same name and different parameters. This fails with pythonnet 2.1.0
I have prepared minimal test functions like this, which return the input para string as string, int or float:
public String Function(String para, ref String myout)
public String Function(String para,ref int myout)
public String Function(String para,ref float myout)

and call them like this
from Test import TestClass
dummy=TestClass()

print dummy.Function('Echo',str())
print dummy.Function('42',int())
print dummy.Function('3.144',float())

With pythonnet==2.0.0 the result is as expected
(u'Echo', u'Echo')
(u'42', 42.0)
(u'3.144', 3.144)

pythonnet==2.1.0 returns a TypeError: No method matches given arguments

I have a sample dll and py as a zip, but unfortunately the upload fails.
(Unfortunately, we don’t support that file type. )